Antimalarial drugs and their actions

Antimalarial drugs and their actions.

New antimalarial drugs are required, partly because of the emergence of drug resistant strains of malaria parasites and partly because better compounds are needed to cure relapsing tertian malaria. In reviewing the diverse modes of action of currently used antimalarials, against a background of the pathogenesis of malaria, attention is drawn to deficiencies in our knowledge. Even less do we und...

Pharmacokinetics of antimalarial drugs: their therapeutic and toxicological implications.

Riassunto (Farmacocinetica dei farmaci antimalarici: implicazioni terapeutiche e tossicologiche). Recenti studi sulla farmacocinetica di farmaci antimalarici in uso corrente hanno portato ad accumulare dati cospicui sul loro assorbimento, sulla loro distribuzione, sul loro metabolismo e sulla loro escrezione. Questi dati forniscono una base razionale per un uso più efficace e più sicuro di ques...

How do antimalarial drugs reach their intracellular targets?

Drugs represent the primary treatment available for human malaria, as caused by Plasmodium spp. Currently approved drugs and antimalarial drug leads generally work against parasite enzymes or activities within infected erythrocytes. To reach their specific targets, these chemicals must cross at least three membranes beginning with the host cell membrane. Uptake at each membrane may involve part...

Antimalarial drugs and glucose metabolism.

the diastereoisomer of quinine, can also cause this compliAn accurate and promptly-available blood or plasma glucose cation [2]. The 4-aminoquinoline chloroquine is known to concentration may, on its own, be very useful clinically but influence glucose metabolism in ways which could lead to is a limited measure of glucose tolerance in a patient with a low blood glucose concentrations [3, 4], al...

Effectiveness of antimalarial drugs.